What Is It?

Understanding HMB

Beta‑hydroxy‑beta‑methylbutyrate (HMB) is a supplement that many active people use, such as bodybuilders, athletes, and fitness lovers.

HMB is made in the body from leucine. Leucine is one of three branched‑chain amino acids and one of nine essential amino acids. Taking leucine helps your muscles make new protein and slows down muscle breakdown.

How It Works?

How HMB Works?

HMB helps the body in several ways: it supports protein use, improves how insulin works, and encourages muscles to grow. Its performance benefits come mainly from protecting muscle‑cell walls, slowing protein breakdown, reducing cell death, boosting protein building through the mTOR pathway, activating the growth‑hormone / IGF‑1 system, and helping muscle stem cells multiply and mature.

For clarity, stem cells are special cells that can make more copies of themselves (self‑renew) and can also turn into other cell types (differentiate). They are present in almost every tissue. Stem‑cell proliferation means the number of stem cells increases, while differentiation is the process where immature stem cells develop into fully specialized cells that perform specific functions.

Benefits

OVERALL TAKEAWAY

HMB is a very strong helper for building muscle: it boosts protein creation in your muscles and fights the breakdown of the muscle you already built. Taking HMB gives solid support to every workout and helps you reach your best possible results over time. With regular use, it can improve your performance, speed up recovery, and increase muscle size, strength, power, and endurance, while also leading to a better overall body composition.

Every Day Impact of HMB Supplementation and Science-Backed Results You Can Trust

Taking HMB each day can help your muscles grow stronger and more powerful when you lift weights. It also shapes your body by lowering body‑fat levels and adding lean muscle. In addition, HMB lessens the muscle damage that comes from hard training, whether you are lifting or doing long‑distance cardio, and it lets you recover faster between sessions.

After a Short Resistance‑Training Program plus Daily HMB (about six weeks)

Regular HMB use during a brief weight‑training cycle can raise resting levels of the muscle‑building hormones growth hormone and IGF‑1, while lowering catabolic hormones that break muscle down. This shift creates a strong, muscle‑friendly hormone balance that supports better performance and growth.

Proven and Science‑Backed Results You Can Trust

Research shows that HMB works mainly by strengthening the muscle‑cell membrane (the sarcolemma) and by slowing down internal pathways that break proteins apart.

For more than 15 years, studies have reported clear performance benefits from HMB. Athletes using it have seen muscle gains, greater fat use, less muscle breakdown, and better aerobic fitness (Asadi et al., 2017; Silva et al., 2017; Arazi et al., 2015; Wilson et al., 2014).

The first key study was published in 1996 by Nissen et al. Untrained men took either 1.5 g or 3 g of HMB daily for three weeks while lifting weights. Compared with the placebo group, the men using HMB raised total strength by 13 % with 1.5 g and by 18.4 % with 3 g. Lean mass went up by 1.2 kg and 4 kg, respectively.

In 2014, Wilson et al. showed that 12 weeks of 3 g HMB per day led to large strength gains in both upper‑ and lower‑body lifts. Participants added 1.8 kg of total body mass, 5.3 kg of fat‑free mass, lost 3.4 kg of fat, and increased quadriceps thickness by 4.8 mm.

Asadi et al. (2017) confirmed similar results over six weeks: 3 g of HMB per day combined with resistance training boosted both strength and power.

For endurance athletes, Knitter et al. (2000) tested 3 g of HMB daily in runners covering at least 48 km per week. After a 20‑km race, markers of muscle damage were far lower in the HMB group, showing that the supplement reduced exercise‑induced muscle damage.

Finally, Asadi et al. (2017) also found that six weeks of 3 g daily HMB raised anabolic hormones (growth hormone and IGF‑1) and lowered catabolic hormones such as cortisol, further supporting muscle growth and recovery.

Be KRE18 Elite, No Limits!

The KRE18 Elite Team and Community, all dedicated athletes, and demanding training sessions and consistent high-performance efforts require only the highest quality supplements to reliably and steadily maximize results, especially, long-term. The KRE18 Pre-Workout Booster ready-to-drink product includes a potent and highly efficacious 1.5-gram dose of myHMB® Clear HMB Acid, can be taken as a science-backed, results-driven performance-enhancement supplement whenever you may need it most, and would be the perfect next-level addition or superior alternative to your current pre-workout supplementation stack. Additionally, the KRE18 Muscle Fuel and Recovery ready-to-drink product also includes a powerful, results-proven 1.5-gram dose of myHMB® Clear HMB Acid and would be the ideal, game-changing addition or superior alternative to your current post-workout and muscle support, growth, and/or recovery supplementation stack.

Written By

Dr. Matt Gaston Villanueva, Ph.D.

Chief Scientific Officer, 

KRE18 Performance