Understanding Paraxanthine

What Is It?

Understanding Paraxanthine

Paraxanthine (1,7‑dimethylxanthine) is a natural dietary ingredient and the main compound that caffeine turns into in the body; compared with caffeine it is less toxic, does not cause jitters or the same level of anxiety, yet delivers stronger movement‑boosting and wake‑promoting effects and a more pronounced release of the neurotransmitter dopamine.

How It Works?

How Paraxanthine Works?

Scientists believe paraxanthine can boost exercise performance through several closely linked actions. First, it raises the burning of free fatty acids, which saves stored muscle glycogen, and—like caffeine—blocks adenosine receptors, a change that keeps the nervous system more alert. It also increases lipolysis, further releasing fats for fuel. In the brain, its adenosine‑blocking effect stimulates the central nervous system, supporting greater stamina and quicker recovery. Unlike caffeine, paraxanthine also amplifies nitric oxide (NO) signaling. Higher NO widens blood vessels, improves blood flow, and has been tied to better aerobic performance and cardiovascular health. More blood reaching working muscles can raise work efficiency, fine‑tune force production, and slow the breakdown of phosphocreatine, all of which add up to stronger muscular and athletic output.

Benefits

OVERALL TAKEAWAY

Paraxanthine is a powerful stand‑alone supplement that sharply boosts mental focus and steady energy, letting you push your performance to the max without the jitters or other side effects people often get from caffeine.

Every Day Impact of Paraxanthine Supplementation and Science-Backed Results You Can Trust

Paraxanthine acts like a clean, high‑octane stimulus: it lifts alertness, cuts fatigue, sharpens focus, and ramps up both muscle endurance and strength while speeding reaction time. Because it clears adenosine receptors and fuels dopamine more efficiently than caffeine—yet causes no jitters or insomnia—you can train or compete at full throttle every day without the usual caffeine crash or nervous overstimulation. The extra mental clarity and steady energy translate into higher training output for bodybuilders, physique athletes, fitness models, gamers, students, and driven professionals alike; you stay locked in a flow state for hours, finish strong, and never feel a drop‑off afterward.

Paraxanthine’s shorter half‑life means it exits the body much faster than caffeine, so restful, uninterrupted sleep remains easy to achieve. It is also non‑habit‑forming and carries a lower toxicity profile, making it a remarkably safe nootropic choice for long‑term use.

Latest studies in humans back these claims. In 2024, Yoo and colleagues showed that runners who ingested 200 mg of paraxanthine before a 10 km run displayed faster reaction times and clearer post‑run focus, with zero negative side effects. Their earlier 2021 study reported that the same dose sharpened short‑term memory, attention, reasoning, and overall cognitive speed. Animal work adds more promise: Jäger et al. (2022) found that paraxanthine doubled nitric‑oxide levels, boosted muscle size, strength, and endurance, and even improved cardiovascular markers by raising HDL while lowering total cholesterol, LDL, and triglycerides.

Be KRE18 Elite, No Limits!

The KRE18 Elite Team and Community, all dedicated athletes, and demanding training sessions and mental efforts require only the highest quality supplements to consistently maximize results, especially, long-term. The KRE18 Energy Booster and KRE18 Pre-Workout Booster ready-to-drink products both include a 200-milligram dose of enfinity® paraxanthine, can be taken as pure standalone focus- and/or performance-enhancement supplements whenever you may need them most, and would be the perfect additions or superior alternatives to your current daily energy/vitality and/or pre-workout supplementation stack.

Written By

Dr. Matt Gaston Villanueva, Ph.D.

Chief Scientific Officer,

KRE18 Performance