What Is It?

Understanding Vitamins B3 (Niacinamide), B6 (Pyridoxine Hydrochloride), and B12 (Methylcobolamin)

VITAMIN B3
Vitamin B3, also known as niacin, is a water-soluble vitamin essential for various physiological processes. It plays a critical role in energy metabolism, DNA repair, and the synthesis of key molecules such as nicotinamide adenine dinucleotide (NAD) and its phosphate form (NADP). NAD and NADP are vital for cellular energy production and redox reactions.

Vitamin B3 is found in various foods, including animal products (e.g., meat, poultry, fish), plant-based sources (e.g., whole grains, nuts, seeds), and fortified foods (e.g., breakfast cereals).

VITAMINS B6 and B12
Vitamins B6 and B12 are also water-soluble vitamins and, like vitamin B3, are essential for various physiological processes. Specifically, vitamins B6 and B12 are involved in energy production, brain function, and DNA synthesis. They play particularly crucial roles in maintaining optimal health.

Rich food sources of vitamin B6 include poultry (e.g., chicken and turkey), fish (e.g., salmon and tuna), potatoes, bananas, and fortified cereals.

Rich food sources of vitamin B12 include meat (e.g., beef), dairy products (e.g., milk and cheese), and fortified plant-based foods (e.g., soy milk).

How It Works?

How Vitamins B3, B6, and B12 Work?

VITAMIN B6

Vitamin B6 is involved in over 100 enzymatic reactions in the human body, primarily related to protein metabolism.

It also plays a vital role in neurotransmitter synthesis, hemoglobin production, and immune function.

Key Roles of Vitamin B6

  • Amino Acid Metabolism: Acts as a coenzyme in amino acid transformations, including the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA) (Stach et al., 2021).
  • Immune Support: Promotes the production of lymphocytes and interleukins, enhancing immune responses (Stach et al., 2021).
  • Cognitive Health: High levels of pyridoxal phosphate (PLP), the active form of vitamin B6, are associated with a reduced risk of cognitive decline (Kennedy, 2016).

VITAMIN B12

Vitamin B12 is crucial for DNA synthesis, red blood cell formation, and neurological function.

It is unique among vitamins because it is stored in significant amounts in the liver.

Key Roles of Vitamin B12

  • DNA Synthesis: Essential for the replication of genetic material during cell division.
  • Neurological Function: Maintains the integrity of the myelin sheath around nerves, which is necessary for proper signal transmission (Kennedy, 2016).
  • Red Blood Cell Production: Prevents megaloblastic anemia by supporting healthy erythropoiesis.

BENEFITS

OVERALL TAKEAWAY

Vitamin B3 is a vital nutrient with diverse roles influencing human health, and, when used strategically, intelligently, and safely as a supplement, can offer potential powerful benefits influencing and impacting cardiovascular health, cancer prevention, and aging-related diseases.

Both Vitamin B6 and Vitamin B12 are fundamental for optimized human health, in particular, due to their roles in metabolism, neurological function, and disease prevention. While deficiencies can lead to serious health issues, such as anemia or cognitive decline, supplementation (under medical guidance) can very likely restore ideal levels effectively.

Every Day Impact of Vitamin B3, B6, and B12 Supplementation and Science-Backed Results You Can Trust

Health Benefits of Vitamin B3, B6, and B12

  • Mental Health: High-dose vitamin B6 supplementation has been shown to reduce anxiety by enhancing GABAergic inhibition in the brain (Field et al., 2022).
  • Neurological Protection: Adequate vitamin B12 levels prevent cognitive decline
  • Energy Production: Facilitates the conversion of food into cellular energy by aiding in fatty acid metabolism
  • Mood Regulation: Deficiency has been linked to depression and anxiety due to its role in neurotransmitter synthesis (Field et al., 2022)
  • A study by Field et al. (2022) demonstrated that high-dose supplementation (100 mg/day) significantly reduced anxiety levels by increasing GABA activity in the brain.
  • Supplementation with 1,000 mcg/day showed trends toward improved visual processing and anxiety reduction (Field et al., 2022).

Be KRE18 Elite, No Limits!

The KRE18 Elite Team and Community, made up of dedicated athletes who undergo demanding training sessions and strive for consistent high performance, rely on only the highest quality supplements to maximize results—especially in the long term. The KRE18 Energy Booster, a ready-to-drink product, delivers safe, potent, and highly efficacious doses of vitamin B3 (Niacinamide: 16 micrograms), B6 (Pyridoxine Hydrochloride: 1.7 milligrams), and B12 (Methylcobalamin: 12 micrograms). It can be taken as a science-backed, results-driven performance-enhancement supplement whenever it's needed most and serves as a perfect next-level addition—or a superior alternative—to your current pre-workout supplementation stack.

Written By

Dr. Matt Gaston Villanueva, Ph.D.

Chief Scientific Officer, 

KRE18 Performance